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COMBIGAN: ADVERSE REACTIONS
Clinical Studies Experience
Because clinical studies are conducted under widely varying conditions, adverse reaction rates observed in the clinical studies of a drug cannot be directly compared to rates in the clinical studies of another drug and may not reflect the rates observed in practice.
In clinical trials of 12 months duration with Combigan (Brimonidine Tartrate, Timolol Maleate ophthalmic solution), the most frequent reactions associated with its use occurring in approximately 5% to 15% of the patients included: allergic conjunctivitis, conjunctival folliculosis, conjunctival hyperemia, eye pruritus, ocular burning, and stinging. The following adverse reactions were reported in 1% to 5% of patients: asthenia, blepharitis, corneal erosion, depression, epiphora, eye discharge, eye dryness, eye irritation, eye pain, eyelid edema, eyelid erythema, eyelid pruritus, foreign body sensation, headache, hypertension, oral dryness, somnolence, superficial punctate keratitis, and visual disturbance.
Other adverse reactions that have been reported with the individual components are listed below.
Brimonidine Tartrate (0.1%-0.2%)
Abnormal taste, blepharoconjunctivitis, allergic reaction, blurred vision, cataract, bronchitis, conjunctival blanching, conjunctival hemorrhage, conjunctival edema, conjunctivitis, cough, dyspepsia, dizziness, dyspnea, flu syndrome, fatigue, follicular conjunctivitis, hypercholesterolemia, gastrointestinal disorder, hypotension, hordeolum, infection (primarily colds and respiratory infections), insomnia, lid crusting, keratitis, lid disorder, nasal dryness, muscular pain, ocular allergic reaction, photophobia, pharyngitis, rash, sinus infection, rhinitis, sinusitis, tearing, superficial punctate keratopathy, upper respiratory symptoms, vitreous detachment, visual field defect, vitreous disorder, vitreous floaters, and worsened visual acuity.
Timolol (Ocular Administration)
Body as a whole: chest pain;
Cardiovascular: Arrhythmia, cardiac arrest, bradycardia, cardiac failure, cerebral vascular accident, cerebral ischemia, claudication, edema, cold hands and feet, heart block, pulmonary edema, palpitation, Raynaud's phenomenon, syncope, and worsening of angina pectoris;
Digestive: diarrhea, anorexia, nausea;
Immunologic: Systemic lupus erythematosus;
Nervous System / Psychiatric: Increase in signs and symptoms of myasthenia gravis, nightmares, insomnia, paresthesia, hallucinations, behavioral changes and psychic disturbances including confusion, anxiety, nervousness, disorientation, and memory loss;
Skin: Alopecia, psoriasiform rash or exacerbation of psoriasis;
Hypersensitivity: Signs and symptoms of systemic allergic reactions, including anaphylaxis, urticaria, angioedema, and generalized and localized rash;
Respiratory: Bronchospasm (predominantly in patients with pre-existing bronchospastic disease), nasal congestion, dyspnea, respiratory failure, upper respiratory infections;
Endocrine: Masked symptoms of hypoglycemia in diabetes patients;
Special Senses: diplopia, choroidal detachment following filtration surgery, cystoid macular edema, decreased corneal sensitivity, pseudopemphigoid, ptosis, refractive changes, tinnitus;
Urogenital: Decreased libido, Peyronie's disease, impotence, retroperitoneal fibrosis.
The following reactions have been identified during post-marketing use of brimonidine tartrate ophthalmic solutions, timolol ophthalmic solutions, or both in combination, in clinical practice. Because they are reported voluntarily from a population of unknown size, estimates of frequency cannot be made. The reactions, which have been chosen for inclusion due to either their seriousness, frequency of reporting, possible causal connection to brimonidine tartrate ophthalmic solutions, timolol ophthalmic solutions, or a combination of these factors, include: eyelid erythema extending to the cheek or forehead, hypersensitivity, keratoconjunctivitis sicca, iritis, miosis, nausea, skin reactions (including rash, erythema, and vasodilation), and tachycardia. In infants, apnea, coma, bradycardia, hypothermia, lethargy, hypotonia, pallor, respiratory depression, and somnolence have been reported.
Oral Timolol / Oral Beta-blockers
The following additional adverse reactions have been reported in clinical experience with ORAL timolol maleate or other ORAL beta-blocking agents and may be considered potential effects of ophthalmic timolol maleate:
Allergic: Erythematous rash, laryngospasm with respiratory distress, fever combined with aching and sore throat;
Body as a whole: Decreased exercise tolerance, weight loss, extremity pain;
Cardiovascular: Worsening of arterial insufficiency, vasodilatation;
Digestive: Gastrointestinal pain, ischemic colitis, hepatomegaly, mesenteric arterial thrombosis, vomiting;
Hematologic: Agranulocytosis, thrombocytopenic purpura, nonthrombocytopenic purpura;
Endocrine: Hyperglycemia, hypoglycemia;
Skin: Increased pigmentation, pruritus, skin irritation, sweating;
Nervous System / Psychiatric: An acute reversible syndrome characterized by disorientation for time and place, decreased performance on neuropsychometrics, diminished concentration, emotional lability, local weakness, reversible mental depression progressing to catatonia, slightly clouded sensorium, vertigo;
Respiratory: Bronchial obstruction, rales;
Urogenital: Urination difficulties.
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